ICI 118551 Hydrochloride

Name	ICI 118551 Hydrochloride
Synonyms	CS-769 ICI 118 551 hydrochloride CI 118551 Hydrochloride ICI 118551 Hydrochloride (±)-erythro-(S,S)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanolhydrochloride
CAS	72795-01-8

Molecular Formula	C17H28ClNO2
Molar Mass	313.86272
Appearance	powder
Color	white
Storage Condition	desiccated
In vitro study	ICI 118551 inhibits cAMP accumulation with IC 50 of 1.7 μM in IMCD cells. ICI 118551 (10 μM) induces a prominent vasorelaxation of norepinephrine (NE)-precontracted PA but not AO. In failing human heart, ICI 118551 has significant effects on beat duration, with time-to-peak contraction and time-to-90% relaxation reduced compared with basal contraction. Negative Inotropic Effect of ICI 118551 Is Not cAMP-Related. Overexpression of β2AR in rabbit myocytes enhances negative inotropic effects of ICI 118551.
In vivo study	ICI 118551 (0.2 mg/kg) injected into the jugular vein of the mice, reduces systolic pressure in the pulmonary circuit but not systemic arterial pressure.

WGK Germany

Last Update：2024-01-02 23:10:35

biological activity	ICI 118,551 hydrochloride is a highly selective β2 adrenergic receptor antagonist that binds to β2, the Ki values of β1 and β3 adrenergic receptors are 0.7,49.5 and 611 nM, respectively.
Target	Ki: 0.7nM (β2 receptor), 49.5 nM (β1 receptor), 611 nM (β3 receptor)

Last Update：2024-04-09 21:54:55

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Product Name: ICI 118551 Hydrochloride Visit Supplier Webpage Request for quotation
CAS: 72795-01-8
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

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ICI 118551 Hydrochloride

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